Apoptosis as a therapeutic beats by dre sale tool in rheumatoid arthritis chpdrdrebtssolo Monocytes are attRacted to the rheumatoid beats by dre outlet store arthritis(Ra)Joint, where they differentiate into macrophages and become activated.They secrete tumournecrosis factor(Tnf)And interleukin1(Il1).Tnf increases the expression of adhesion molecules on endothelial cells, which recruit more cells to the joint.Chemokines, such as monocyte chemotactic protein 1(Mcp1)And il8, are also secreted by macrophages and attract more cells into the joint.Il1 and tnf induce synovial fibroblasts to express cytokines(Such as il6), chemokines(Such as il8), growth factors(Such as granulocyte colonystimulating factor;Gmcsf)And matrix metalloproteinases(Mmps), which contribute to cartilage and bone destruction.Tnf contributes to osteoclast activation and differentiation.In addition, il1 mediates cartilage degradation directly by inducing the expression of mmps by chondrocytes.

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